Biocurcumax (BCM-95® Curcugreen®) Clinical Research

BCM-95® (CURCUGREEN®) is the most researched bioavailable curcumin in the world with over 75 clinical studies in high impact publications covering a wide range use cases. Studies are listed below and can be clicked to view more details on a particular study.

A detailed Clinical Research Overview was also carried out by the American Botanical Council  in 2019 reviewing many of the applications of Biocurcumax, its effects on health and supporting research – this can be read here or downloaded from the button below.

READ AMERICAN BOTANICAL COUNCIL CLINICAL RESEARCH REVIEW

JOINT HEALTH STUDIES

Bioavailable turmeric extract for knee osteoarthritis: a randomized, non-inferiority trial versus paracetamol. Trials 22, 105 (2021). https://doi.org/10.1186/s13063-021-05053-7 Singhal, S., Hasan, N., Nirmal, K. et al.
Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study. Trials. 2019;20(1):214.
Clinical evaluation of a formulation containing Curcuma longa and Boswellia serrata extracts in the management of knee osteoarthritis. Molecular medicine reports, 2013
Clinical Evaluation Of A Herbal Formulation, Rhulief™, In The Management Of Knee Osteoarthritis. Osteoarthritis And Cartilage. 2011 Sep 1;19:S145-6
Evaluation of the articular cartilage in the knees of rats with induced arthritis treated with curcumin. PLoS ONE. 2020; 15(3): e0230228.
Shep D, Khanwelkar C, Gade P, Karad S. Efficacy and safety of combination of curcuminoid complex and diclofenac versus diclofenac in knee osteoarthritis: a randomized trial. Medicine 2020;99:16(e19723).
The efficacy and safety of a combination of glucosamine hydrochloride, chondroitin sulfate and bio-curcumin with exercise in the treatment of knee osteoarthritis: a randomized, double-blind, placebo-controlled study, European Journal of Physical and Rehabilitation Medicine [2016, 52(3):321-330]
Short Report of a Preliminary Open Study of Synofit-Containing Bio-Curcumin, Greenlipped Mussel and Blackcurrant Leaf Extract in Arthritis, Open Journal of Rheumatology and Autoimmune Diseases, 5, 113-117. doi: 10.4236/ojra.2015.54018.
A Randomized, Pilot study to assess the Efficacy and Safety of Curcumin in Patients with Active Rheumatoid Arthritis. Phytotherapy Research 2012; OI:10.1002/ptr.4639
A Randomized Controlled Trial Of Curcumin And Diclofenac Combination In Knee Osteoarthritis. Shep D, Khanwelkar C, Gade P, Karad S. Int J Curr Pharm Sci [Internet]. 2019nov.15 [Cited 2020may4];11(6):111-4.

LIVER HEALTH STUDIES

a. Evaluation Of Hepatoprotective Activity Of Combination Of Phyllanthus Niruri And Curcuma Longa Extracts In Wistar Rats. (POSTER)

b. Evaluation of Hepatoprotective activity of combination of Phyllanthus niruri and Curcuma longa extracts in Wistar rats. Res. J. Pharm., Biol. Chem. Sci. 2012:1260-1268

c. Hepatoprotective activity of combination of Phyllanthus niruri and Curcuma longa extracts against ethanol induced toxicity in wistar rats. International Journal of Pharma and Bio Sciences. 2016;7(1):P12-8.

Effect of curcumin supplementation on serum expression of select cytokines and chemokines in a female rat model of nonalcoholic steatohepatitis. BMC research notes. 2019 Dec;12(1):1-7
Comparing different non-invasive methods in assessment of the effects of curcumin on hepatic fibrosis in patients with non-alcoholic fatty liver disease. Gastroenterology and hepatology from bed to bench. 2018;11(Suppl 1):S8.
a. Curcumin supplementation mitigates NASH development and progression in female Wistar rats. Physiological reports. 2018 Jul;6(14):e13789.
b. Curcumin Supplementation Mitigates Nash Development and Progression in Female Wistar Rats: 2926 Board# 209 June 1 3. Medicine & Science in Sports & Exercise. 2018 May 1;50(5S):724.
The effects of curcumin supplementation on liver enzymes, lipid profile, glucose homeostasis, and hepatic steatosis and fibrosis in patients with non-alcoholic fatty liver disease. European journal of clinical nutrition. 2019 Jan 4:1.
Curcumin and inflammation in non-alcoholic fatty liver disease: a randomized, placebo controlled clinical trial. BMC gastroenterology. 2019 Dec;19(1):133.

CANCER STUDIES

A Pilot Clinical Trial of Radioprotective Effects of Curcumin Supplementation in Patients with Prostate Cancer. Hejazi et al., J Cancer Sci Ther 2013,
Novel Evidence for Curcumin and Boswellic Acid-Induced Chemoprevention through Regulation of miR-34a and miR-27a in Colorectal Cancer. Cancer Prev Res (Phila). 2015 May;8(5):431-43.
Curcumin potentiates antitumor activity of 5-fluorouracil in a 3D alginate tumor microenvironment of colorectal cancer. BMC Cancer. 2015 Apr 10;15:250.
Curcumin and metformin-mediated chemoprevention of oral cancer is associated with inhibition of cancer stem cells. Molecular Carcinogenesis. 2017; 56:2446–2460.
Curcumin sensitizes pancreatic cancer cells to gemcitabine by attenuating PRC2 subunit EZH2, and the lncRNA PVT1 expression. Carcinogenesis. 2017 Oct 1;38(10):1036-46.
Role of curcumin as an adjuvant in treatment of advanced head and neck squamous cell carcinoma. Int J Otorhinolaryngol Head Neck Surg 2018;4:1388-93
Curcumin inhibits cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1α signaling. International journal of oncology. 2015 Dec 1;47(6):2064-72.
Curcumin Inhibits Polycomb Repressive Complex 2 through lncRNA-PVT1 and Enhances Gemcitabine Sensitivity in Chemoresistant Pancreatic Cancer. Gastroenterology. 2016 Apr 1;150(4):S624.
Curcumin Suppresses Crosstalk between Colon Cancer Stem Cells and Stromal Fibroblasts in the Tumor Microenvironment: Potential Role of EMT. PLoS ONE 9(9): e107514.
BreastDefend™ prevents breast-to-lung cancer metastases in an orthotopic animal model of triple-negative human breast cancer. Oncology reports. 2012 Oct 1;28(4):1139-45.
Role of turmeric extract in minimising mucositis in patients receiving radiotherapy for head and neck squamous cell cancer: a randomised, placebocontrolled trial. J Laryngol Otol 2020;1–6
Suppression of Proliferation and Invasive Behavior of Human Metastatic Breast Cancer Cells by Dietary Supplement BreastDefend. J Jiang, R Wojnowski, A Jedinak… – Integrative Cancer Therapies 10(2) 192–200(2011)
Effect of Curcumin Supplementation During Radiotherapy on Oxidative Status of Patients with Prostate Cancer: A Double Blinded, Randomized, Placebo-Controlled Study; Hejazi J, Rastmanesh R, Taleban FA, Molana SH, Hejazi E, Ehtejab G, Hara N; Nutr Cancer. 2016;68(1):77-85. doi: 10.1080/01635581.2016.1115527.
Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer. Carcinogenesis. 2015 Mar;36(3):355-67
Curcumin Chemosensitizes 5-Fluorouracil Resistant MMR-Deficient Human Colon Cancer Cells in High Density Cultures. PLoS ONE 9(1): e85397.
A randomized double-blind placebo-controlled phase IIB trial of curcumin in oral leukoplakia, DOI: 10.1158/1940-6207.CAPR-15-0390 Published 7 June 2016
Suppression of growth and invasive behavior of human prostate cancer cells by ProstaCaidTM: Mechanism of activity. Jia hua Jiang, Isaac Eliaz and Dani el Sliva international journal of oncology 38: 1675-1682, 2011
ProstaCaid™ inhibits tumor growth in a xenograft model of human prostate cancer. International journal of oncology. 2012 May 1;40(5):1339-44.
ProstaCaid Induces G2/M Cell Cycle Arrest and Apoptosis in Human and Mouse Androgen– Dependent and – Independent Prostate Cancer Cells. Integrative Cancer Therapies 9(2) 186–196
A combination of curcumin and oligomeric proanthocyanidins offer superior anti-tumorigenic properties in colorectal cancer. Scientific reports. 2018 Sep 14;8(1):13869.
Synergistic and additive effects of modified citrus pectin with two polybotanical compounds, in the suppression of invasive behavior of human breast and prostate cancer cells. Integr Cancer Ther. 2013 Mar;12(2):145-52. Epub 2012 Apr 24.
A novel cancer preventative botanical mixture, TriCurin, inhibits viral transcripts and the growth of W12 cervical cells harbouring extrachromosomal or integrated HPV16 DNA. British Journal of Cancer. 2020 Dec 1:1-3. Einbond LS, Zhou J, Wu HA, Mbazor E, Song G, Balick M, DeVoti JA, Redenti S, Castellanos MR. 
Natural agents inhibit colon cancer cell proliferation and alter microbial diversity in mice. PLoS ONE 15(3): e0229823. Farhana L, Sarkar S, Nangia-Makker P, Yu Y, Khosla P, Levi E, et al. (2020)