BCM-95® (CURCUGREEN®)

Clinical Research

BCM-95® (CURCUGREEN®) is the most researched bioavailable curcumin in the world with over 68 clinical studies in high impact publications. A selection of these are presented.

A detailed Clinical Research Overview was also carried out by the American Botanical Council reviewing many of its applications, effects on health and supporting research – this can be read or downloaded on the link below.

Read American Botanical Council Clinical Research Overview

BIOAVAILABILITY

Bioavailability

Bioavailability of BiocurcumaxTM (BCM-095TM), Spice India 2006 (Sept);11-15

Bioavailability

Enhancing the Absorption of Curcuminoids, Spice India 2005(July); 23-26

Bioavailability

Comparative bioavailability of curcumin, turmeric and Biocurcumax™ in traditional vehicles using non-everted rat intestinal sac model. J Funct Foods. 2010;2(1):60–5

Bioavailability Studies

Oral Bioavailability of BCM-95® in Dogs” Poster presentation. 2009 ACVIM Forum/ Canadian VMA Convention: June 3-6, 2009;Montréal, Québec, Canada

Bioavailability Studies

A Pilot Cross-Over Study to Evaluate Human Oral Bioavailability of BCM-95®CG (Biocurcumax™), A Novel Bioenhanced Preparation of Curcumin, Indian J Pharm Sci 2008;70(4):445-449

JOINT HEALTH

Joint Health Studies

Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study. Trials. 2019;20(1):214.

Joint Health

Clinical evaluation of a formulation containing Curcuma longa and Boswellia serrata extracts in the management of knee osteoarthritis Molecular medicine reports, 2013

Joint Health

Clinical Evaluation Of A Herbal Formulation, Rhulief™, In The Management Of Knee Osteoarthritis. Osteoarthritis And Cartilage. 2011 Sep 1;19:S145-6

Joint Health Studies

Evaluation of the articular cartilage in the knees of rats with induced arthritis treated with curcumin. PLoS ONE. 2020; 15(3): e0230228. https://doi. org/10.1371/journal.pone.0230228

Joint Health Studies

Shep D, Khanwelkar C, Gade P, Karad S. Efficacy and safety of combination of curcuminoid complex and diclofenac versus diclofenac in knee osteoarthritis: a randomized trial. Medicine 2020;99:16(e19723).

Joint Health

Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study, BMC Complementary and Alternative Medicine, 2018 18:7

Joint Health

The efficacy and safety of a combination of glucosamine hydrochloride, chondroitin sulfate and bio-curcumin with exercise in the treatment of knee osteoarthritis: a randomized, double-blind, placebo-controlled study, European Journal of Physical and Rehabilitation Medicine [2016, 52(3):321-330]

Joint Health

Short Report of a Preliminary Open Study of Synofit-Containing Bio-Curcumin, Greenlipped Mussel and Blackcurrant Leaf Extract in Arthritis, Open Journal of Rheumatology and Autoimmune Diseases, 5, 113-117. doi: 10.4236/ojra.2015.54018.

Joint Health

A Randomized, Pilot study to assess the Efficacy and Safety of Curcumin in Patients with Active Rheumatoid Arthritis. Phytotherapy Research 2012; OI:10.1002/ptr.4639

PAIN MANAGEMENT STUDIES

Pain Management Studies

Curcumin downregulates expression of opioid-related nociceptin receptor gene (OPRL1) in isolated neuroglia cells. Phytomedicine. 2018 Nov 15;50:285-99.

Pain Management Studies

Evaluation of Antinociceptive Activity of Bcm95 and Bospure® in Rodents. Indian Journal of Pharmacology, December 2013, Volume 45, Supplement S187.

MAJOR DEPRESSION STUDIES

Major Depression Studies

Efficacy and safety of curcumin in major depressive disorder: a randomized controlled trial. Phytother Res. 2014 Apr;28(4):579-85.

Major Depression Studies

Curcumin and major depression: A randomised, double-blind, placebo-controlled trial investigating the potential of peripheral biomarkers to predict treatment response and antidepressant mechanisms of change. European Neuropsychopharmacology , Volume 25 , Issue 1 , 38 – 50

Depression Studies

Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled study. Lopresti AL, Drummond PD, J Affect Disord. 2017; 207:188-196. doi: 10.1016/j.jad.2016.09.047.

Major Depression Studies

Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study. J Affect Disord. 2014;167:368-75.

Depression Studies

Evaluation of antidepressant like activity of Curcumin and its combination with Fluoxetine and Imipramine: An acute and chronic study, Acta poloniae pharmaceutica ñ drug research, vol. 68 no. 5 pp. 769-775, 2011

ANTI-INFLAMMATORY STUDIES

Anti-Inflammatory

The use of an anti-inflammatory supplement in patients with chronic kidney disease. Journal of Complementary and Integrative Medicine. 2013 Jul 1;10(1):143-52.

Anti-Inflammatory

Effect of Infla-Kine supplementation on the gene expression of inflammatory markers in peripheral mononuclear cells and on C-reactive protein in blood. J Transl Med. 2017 Oct 20;15(1):213. doi: 10.1186/s12967-017-1315-4.

Anti-Inflammatory

Essential turmeric oils enhance anti-inflammatory efficacy of curcumin in dextran sulfate sodium-induced colitis, Scientific Reportsvolume 7, Article number: 814 (2017)

Anti-Inflammatory

a. Impact of a 3-weeks randomized double-blind cross-over study curuminoid supplementation on endotoxemia, inflammatory markers, and lipid profiles in healthy overweight and obese adults. Proceedings of the Nutrition Society. 2016;75(OCE3).

b. Impact of a 3-weeks randomized double-blind cross-over study curuminoid supplementation on endotoxemia, inflammatory markers, and lipid profiles in healthy overweight and obese adults. Proceedings of the Nutrition Society. 2016;75(OCE3).

c. Polyphenol curcuminoids and prevention of endotoxaemia and low-grade inflammation (Doctoral dissertation, University of Glasgow).

Anti-Inflammatory

Effect of citrus polyphenol-and curcumin-supplemented diet on inflammatory state in obese cats. Br J Nutr. 2011 Oct; 106 Suppl 1: S198-2011.

Anti-Inflammatory

Anti-inflammatory activity of BCM-95 (bio-enhanced formulation of turmeric with increased bioavailabilty) compared to Curcumin in Wistar rats, Pharmacognosy Journal, Vol 8, Issue 4, Jul-Aug, 2016 380 -384

DIABETES STUDIES

1

Diabetic Health Studies

The effects of curcumin supplementation on high‐sensitivity C‐reactive protein, serum adiponectin, and lipid profile in patients with type 2 diabetes: A randomized, double‐blind, placebo‐controlled trial. Phytotherapy Research. 2019 Mar 12.
2

Diabetic Health Studies

The effect of curcumin supplementation on anthropometric indices, insulin resistance and oxidative stress in patients with type 2 diabetes: a randomized, double-blind clinical trial. Diabetology & metabolic syndrome. 2019 Dec;11(1):41.

LIVER HEALTH STUDIES

Liver Health Studies

a. Evaluation Of Hepatoprotective Activity Of Combination Of Phyllanthus Niruri And Curcuma Longa Extracts In Wistar Rats. (POSTER)

b. Evaluation of Hepatoprotective activity of combination of Phyllanthus niruri and Curcuma longa extracts in Wistar rats. Res. J. Pharm., Biol. Chem. Sci. 2012:1260-1268

c. Hepatoprotective activity of combination of Phyllanthus niruri and Curcuma longa extracts against ethanol induced toxicity in wistar rats. International Journal of Pharma and Bio Sciences. 2016;7(1):P12-8.

Liver Health Studies

Effect of curcumin supplementation on serum expression of select cytokines and chemokines in a female rat model of nonalcoholic steatohepatitis. BMC research notes. 2019 Dec;12(1):1-7

Liver Health Studies

Comparing different non-invasive methods in assessment of the effects of curcumin on hepatic fibrosis in patients with non-alcoholic fatty liver disease. Gastroenterology and hepatology from bed to bench. 2018;11(Suppl 1):S8.

Liver Health Studies

a. Curcumin supplementation mitigates NASH development and progression in female Wistar rats. Physiological reports. 2018 Jul;6(14):e13789.

b. Curcumin Supplementation Mitigates Nash Development and Progression in Female Wistar Rats: 2926 Board# 209 June 1 3. Medicine & Science in Sports & Exercise. 2018 May 1;50(5S):724.

Liver Health Studies

The effects of curcumin supplementation on liver enzymes, lipid profile, glucose homeostasis, and hepatic steatosis and fibrosis in patients with non-alcoholic fatty liver disease. European journal of clinical nutrition. 2019 Jan 4:1.

Liver Health Studies

Curcumin and inflammation in non-alcoholic fatty liver disease: a randomized, placebo controlled clinical trial. BMC gastroenterology. 2019 Dec;19(1):133.

COGNITIVE HEALTH

Cognitive Health Studies

Evaluation of Antiepileptic and Memory Retention Activity of Curcumin Per SE and in Combination with Antiepileptic Drugs, Asian J Pharm Clin Res. 2014;6(2):145-148

Cognitive Health Studies

a. Risperidone-induced metabolic dysfunction is attenuated by Curcuma longa extract administration in mice; Metab Brain Dis, DOI 10.1007/s11011-017-0133-y (online )

b. Risperidone-induced metabolic dysfunction is attenuated by Curcuma longa extract administration in mice. Metabolic brain disease. 2018 Feb 1;33(1):63-77.

Cognitive Health Studies

Curcumin and cognition: a randomised, placebo-controlled, double-blind study of community-dwelling older adults, British Journal of Nutrition, Volume 115, Issue 12, June 2016, pp. 2106-2113

Alzheimer’s Studies

6-month double-blind, placebo-controlled, pilot clinical trial of curcumin in patients with Alzheimer’s disease, J Clin Psychopharmacol, 2008, 28:110-113

CANCER STUDIES

Cancer Studies

A Pilot Clinical Trial of Radioprotective Effects of Curcumin Supplementation in Patients with Prostate Cancer. Hejazi et al., J Cancer Sci Ther 2013,

Cancer Studies

Novel Evidence for Curcumin and Boswellic Acid-Induced Chemoprevention through Regulation of miR-34a and miR-27a in Colorectal Cancer. Cancer Prev Res (Phila). 2015 May;8(5):431-43.

Cancer Studies

Curcumin potentiates antitumor activity of 5-fluorouracil in a 3D alginate tumor microenvironment of colorectal cancer. BMC Cancer. 2015 Apr 10;15:250.

Cancer Studies

Curcumin and metformin-mediated chemoprevention of oral cancer is associated with inhibition of cancer stem cells. Molecular Carcinogenesis. 2017; 56:2446–2460.

Cancer Studies

Curcumin sensitizes pancreatic cancer cells to gemcitabine by attenuating PRC2 subunit EZH2, and the lncRNA PVT1 expression. Carcinogenesis. 2017 Oct 1;38(10):1036-46.

Cancer Studies

Role of curcumin as an adjuvant in treatment of advanced head and neck squamous cell carcinoma. Int J Otorhinolaryngol Head Neck Surg 2018;4:1388-93

Cancer Studies

Curcumin inhibits cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1α signaling. International journal of oncology. 2015 Dec 1;47(6):2064-72.
8

Diabetic Health Studies

The effects of curcumin supplementation on high‐sensitivity C‐reactive protein, serum adiponectin, and lipid profile in patients with type 2 diabetes: A randomized, double‐blind, placebo‐controlled trial. Phytotherapy Research. 2019 Mar 12.

Cancer Studies

Curcumin Inhibits Polycomb Repressive Complex 2 through lncRNA-PVT1 and Enhances Gemcitabine Sensitivity in Chemoresistant Pancreatic Cancer. Gastroenterology. 2016 Apr 1;150(4):S624.
10

Cancer Studies

Curcumin Suppresses Crosstalk between Colon Cancer Stem Cells and Stromal Fibroblasts in the Tumor Microenvironment: Potential Role of EMT. PLoS ONE 9(9): e107514.

Cancer Studies

BreastDefend™ prevents breast-to-lung cancer metastases in an orthotopic animal model of triple-negative human breast cancer. Oncology reports. 2012 Oct 1;28(4):1139-45.

Cancer Studies

Role of turmeric extract in minimising mucositis in patients receiving radiotherapy for head and neck squamous cell cancer: a randomised, placebocontrolled trial. J Laryngol Otol 2020;1–6

Cancer Studies

Suppression of Proliferation and Invasive Behavior of Human Metastatic Breast Cancer Cells by Dietary Supplement BreastDefend. J Jiang, R Wojnowski, A Jedinak… - Integrative Cancer Therapies 10(2) 192–200(2011)

Cancer Studies

Effect of Curcumin Supplementation During Radiotherapy on Oxidative Status of Patients with Prostate Cancer: A Double Blinded, Randomized, Placebo-Controlled Study; Hejazi J, Rastmanesh R, Taleban FA, Molana SH, Hejazi E, Ehtejab G, Hara N; Nutr Cancer. 2016;68(1):77-85. doi: 10.1080/01635581.2016.1115527.

Cancer Studies

Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer. Carcinogenesis. 2015 Mar;36(3):355-67

Cancer Studies

Curcumin Chemosensitizes 5-Fluorouracil Resistant MMR-Deficient Human Colon Cancer Cells in High Density Cultures. PLoS ONE 9(1): e85397.

Cancer Studies

ProstaCaid Induces G2/M Cell Cycle Arrest and Apoptosis in Human and Mouse Androgen– Dependent and – Independent Prostate Cancer Cells. Integrative Cancer Therapies 9(2) 186–196

Cancer Studies

ProstaCaid™ inhibits tumor growth in a xenograft model of human prostate cancer. International journal of oncology. 2012 May 1;40(5):1339-44.

Cancer Studies

A randomized double-blind placebo-controlled phase IIB trial of curcumin in oral leukoplakia, DOI: 10.1158/1940-6207.CAPR-15-0390 Published 7 June 2016

Cancer Studies

Suppression of growth and invasive behavior of human prostate cancer cells by ProstaCaidTM: Mechanism of activity. Jia hua Jiang, Isaac Eliaz and Dani el Sliva international journal of oncology 38: 1675-1682, 2011

Cancer Studies

A combination of curcumin and oligomeric proanthocyanidins offer superior anti-tumorigenic properties in colorectal cancer. Scientific reports. 2018 Sep 14;8(1):13869.

Cancer Studies

Farhana L, Sarkar S, Nangia-Makker P, Yu Y, Khosla P, Levi E, et al. (2020) Natural agents inhibit colon cancer cell proliferation and alter microbial diversity in mice. PLoS ONE 15(3): e0229823.

Cancer Studies

Synergistic and additive effects of modified citrus pectin with two polybotanical compounds, in the suppression of invasive behavior of human breast and prostate cancer cells. Integr Cancer Ther. 2013 Mar;12(2):145-52. Epub 2012 Apr 24.

MISC HEALTH STUDIES

Autophagy Studies

BCM-95 and (2-hydroxypropyl)-ß-cyclodextrin reverse autophagy dysfunction and deplete stored lipids in Sap C-deficient fibroblasts. Hum Mol Genet. 2015 Apr 29.

Healing Agent Studies

Effect of a topical curcumin preparation (BIOCURCUMAX) on burn wound healing in rats, Journal of Pharmaceutical and Biomedical Sciences (JPBMS), Vol. 08, Issue 08

Curcuminoid Toxicity Studies

Systematic and comprehensive investigation of the toxicity of curcuminoid-essential oil complex: A bioavailable turmeric formulation, MOLECULAR MEDICINE REPORTS 13: 592-604, 2016

General Health Studies

Effect of Biocurcumax TM Curcumin (BCM-95) On Treatment of Moderate Chronic Periodontitis. Journal of Mazandaran University of Medical Sciences. 2018 Mar 15;27(158):45-55.

General Health Studies

The Effect of Exercise and Nutritional Supplementation on Proinflammatory Cytokine Expression in Young Racehorses During Training, J Equine Vet Sci. 2012 December;32(12):805-15

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