Bioavailability is sub-category of absorption, it refers to the amount of a substance that reaches the systemic circulation (bloodstream). It is a well known fact that curcumin is difficult for the body to absorb, this is because it is soluble in fat not water (the digestive system is ‘watery’ ).

The combination of curcumin with the natural oils of turmeric in Biocurcumax ensure extremely high levels of bioavailability (700% more than standard curcumin preparations) with no need for additional non-turmeric  ‘bioenhancers’ such as piperine.

A bioenhancer is an agent capable of enhancing bioavailability and efficacy of a drug with which it is co-administered, without any pharmacological activity of its own at therapeutic dose used.

Biocurcumax:

• Biocurcumax  bioenhancers are actually concentrated essential oils of turmeric that have no other side effects unlike other branded curcumins which have non-turmeric bio enhancers which may have drug interactions
• FDA GRAS (Generally Recognized As Safe) Affirmed
• Uses safe extraction means and is checked in the most sensitive instruments for any contaminants
• Safe from Lead and other heavy metals
• Safe for over 18 years of standing in over 300 formulations in over 60 countries
• The only curcumin for which a detailed toxicity study is published.( Systematic and comprehensive investigation of the toxicity of curcuminoid-essential oil complex: A bioavailable turmeric formulation, MOLECULAR MEDICINE REPORTS 13: 592-604, 2016)

To measure the relative bioavailability, the quantity of free curcumin available in the blood plasma after oral ingestion of Biocurcumax (BCM-95^® CURCUGREEN^® ) is compared to the value obtained when regular Curcumin 95% is ingested. It is the free curcumin in the blood plasma that gives the health benefits of Turmeric

Free Curcumin is freely available in the blood plasma after ingestion of curcumin. Curcumin metabolites are products of the metabolism of curcumin in the body. They do not have known health benefits and are inactive for health purposes.

The methods of increasing bioavailability in Biocurcumax (BCM-95^® CURCUGREEN^®) come from the combination of curcumin with the natural oils of turmeric for high absorption – and is 100% natural, there are no other known risks or interactions.

Popular methods of increasing bioavailability used by alternative brands rely on non-turmeric additives like those used in drug delivery. Unlike the safe method in Biocurcumax (BCM-95® Curcugreen®), this can pose long term health risks or risks of interference in drug delivery by increasing or decreasing delivered drug quantity. Biocurcumax (BCM-95® Curcugreen®) has been extensively studied scientifically to be safe and the results published.

The definition of bio-availability is well known. The objective of understanding bio-availability is to understand what the real world benefit to the consumer of each quantity ingested is.

Curcuminoids undergo complex transformations in the body once ingested. The positive health benefits is limited to free curcumin available in the blood plasma ONLY.

However, this forms only a part of the total curcuminoids. Most of the curcuminoids convert themselves into curcumin metabolites which undergo further changes in the body and are then eliminated. This does not provide any health benefit.

However, working back with an objective to hit a higher ‘numerical value’, it has been a practice to measure total curcuminoids by measuring the inactive curcumin metabolites as well. This serves two purposes, both of which are not favorable to the consumer.

1. It indicates a higher bio activity and the consumer wrongly infers a higher benefit, when this is clearly not the case.
2. The effective dosage is reduced, decreasing any benefit further, while the consumer pays more per effective curcumin.

Needless to say, this is very deceptive.

In contrast BCM-95^® (CURCUGREEN^®) only measures the true free curcumin and ONLY in the extracted blood plasma which gives a very reliable measure of benefit to the consumer

A bio available curcumin has two parts:

1. the curcumin (turmeric extract)
2. the bio-enhancer.

The older approach was to provide a simplistic bioenhancer along with a branded regular curcumin -95%. This approach has many drawbacks. It was left to the final producer of the product to blend the two before making supplements. Also the correct ratio cannot always be guaranteed in each dose.

BCM-95^® (CURCUGREEN^®) was the first to bring a pre formulated product to the market. By synergistically combining curcumin-95% and 45% ar-turmerone enriched turmeric essential oil in a controlled professional environment.

BCM-95^® (CURCUGREEN^®) delivers a consistent product ; consistent in both quality and ratios each time and every time. This translates into predictable and assured benefits.

The bioavailability mechanism of BCM-95^® (CURCUGREEN^®) has been researched and well understood. The results obtained are in line with scientific theories regarding the same.

On oral intake of curcumin, the P glycoprotein in intestinal cells pushes out curcumin back into the gut lumen which is a major rate limiting step in the absorption of curcumin. BCM-95^® (CURCUGREEN^®) is a synergistic blend of curcumin and essential oil of turmeric enriched with turmerones. Turmerones in BCM-95^® (CURCUGREEN^®) inhibit P glycoprotein thereby increasing absorption and bioavailability of curcumin in the body.

Moreover this mechanism causes repeated absorption cycles which is also evidenced by the presence of free curcumin in the blood plasma even after 8 – 9 hours of ingestion.

The constitution of BCM-95^® (CURCUGREEN^®) with turmerones is protected by 53 international patents and is unique to BCM-95^® (CURCUGREEN^®). Hence the effect and efficacy of this process is also unique to BCM-95^® (CURCUGREEN^®).

• Utilized bio enhancers are specially concentrated essential oils of turmeric have no other side effects unlike other branded curcumins which have non-turmeric bio enhancers which may have drug interactions
• GRAS (Generally Recognized As Safe) Affirmed
• Uses safe extraction means and is checked in the most sensitive instruments for any contaminants
• Lead and other heavy metal safe
• Safe for over 18 years of standing in over 300 formulations in over 60 countries
• The only curcumin for which a detailed toxicity study is published.( Systematic and comprehensive investigation of the toxicity of curcuminoid-essential oil complex: A bioavailable turmeric formulation, MOLECULAR MEDICINE REPORTS 13: 592-604, 2016)

A comprehensive study was undertaken (Systematic and comprehensive investigation of the toxicity of curcuminoid-essential oil complex: A bioavailable turmeric formulation, MOLECULAR MEDICINE REPORTS 13: 592-604, 2016) to evaluate the safety of BCM-95^® (CURCUGREEN^®) and the results published.

The detailed toxicity and safety of BCM-95^® (CURCUGREEN^®) was done using in vivo and in vitro models as per OECD guidelines. An acute toxicity study was performed in rats as well as mice. In this study, no toxic signs and symptoms/mortality was observed in any of the animals at the maximum recommended dose level of 5000 mg/kg b.wt. The repeated administration of BCM-95^® (CURCUGREEN^®) for 90 days in wistar rats at the dose level of 1000 mg/kg body weight did not induce any observable toxic effects, when compared to its corresponding control animals.

Mutagenicity (nontoxicity) studies were also performed by Ames test (Bacterial Reverse Mutation Assay), Mammalian Bone Marrow Chromosome Aberration Test and Mammalian Erythrocyte Micronucleus Test in mice. BCM-95^® (CURCUGREEN^®) was found to be non-mutagenic in all the three mutagenicity studies.

The present study clearly indicates that BCM-95^® (CURCUGREEN^®) does not have any toxic effects in animals as well as in vitro. Based upon these observations, it is concluded that the BCM-95^® (CURCUGREEN^®) is non-toxic and safe as evidenced by acute toxicity studies, repeated dose toxicity study and mutagenicity study.

Every batch of BCM-95^® (CURCUGREEN^®) produced is tested at our in-house lab for heavy metals including lead, arsenic, cadmium and mercury. We use the latest and most accurate lab equipment called “ICP-MS” which can detect even minute quantities of substances instead of less accurate conventional Atomic Absorption.

BCM-95^® (CURCUGREEN^®) is the most researched Bio-available curcumin in the world with more than 75 studies conducted worldwide (geographically diverse) and published in reputed journals. Please click here for a selection of published studies on BCM-95. There are also many studies more in various stages of progress or publication.